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R45 | The Reversal

Patented 3-phase retinol night cream that tightens, brightens, smooths and corrects

2 x .17 fl. oz/ 5 ml

or 4 installments of $40.00 USD by Info

Our award-winning R45® The Reversal anti-aging retinol night cream utilizes a patented booster system that is so powerful, you only need to use it twice a year. In just 45 days, this 3-phase retinol treatment for aging is clinically proven to repair all 4 benchmarks of aging – discoloration, wrinkles, enlarged pores and uneven texture. Our proprietary retinol complex, TriGLO™, mimics the skin-smoothing effects of clinical retinol without the harsh side effects. Finally, a retinol every skin type can use. Take the #R45DayChallenge and see for yourself!


  • Smooths Wrinkles
  • Tightens Pores
  • Erases Spots

Key Ingredients


Concentrations of our proprietary retinol complex gradually increase with each phase for a clinically proven reduction in the appearance of wrinkles, skin tone unevenness, skin spots and pore size.

Growth Factor Stimulant Serum

Peptide complex that strengthens skin’s proteins, increases hydration levels and fortifies skin against free radical damage.

Citric Acid

Helps stimulate collagen production and works to diminish dark spots.

Safflower Seed Oil

Combines with skin's sebum to unclog pores, reduce breakouts, and create a protective barrier to retain moisture.


Consumer Results


In a R45 The Reversal consumer perception survey:

100% agreed skin looked better once treatment was completed

95% noticed a visible change in skin

90% felt pores were less noticeable

90% felt skin looked more radiant

90% noticed a reduction in the appearance of wrinkles

Before and After image of R45 The Reversal
Before and After image of R45 The Reversal
Before and After image of R45 The Reversal
R45 The Reversal Consumer Perception Survey Results

R45 - a miracle worker!

- GA

              How to use R45 The Reversal

How To Use

For PM use. Cleanse face and pat dry. Apply 1-2 pumps of R45 The Reversal Phase 1 Regeneration Complex (Side A) + GFS Serum (Side B) to face. After R45 The Reversal Phase 1 is complete, advance to Phase 2 and conclude with Phase 3. Results are cumulative, do not start with Phase 2 or Phase 3. Follow with your favorite moisturizer.

Skinsider Tips:
  • Boost skin with R45 The Reversal 2x a year. 
  • While boosting, take a vacation from other PM treatment serums.  
  • For maximum results, use GLOPRO® FACE MICROTIP™ before applying R45 The Reversal.  
  • Avoid direct eye contact.

Frequently Asked Questions

R45 results are so good, you only need to boost twice a year. Have some problem areas you’d like to target? You can definitely boost more often. When using R45 The Reversal, temporarily press pause on your other nighttime serums, as the treatment will deliver all results without assistance.

One of the best features of R45 is the step-up concentration found in each progressive phase. This patented formula allows your skin to ease into each phase even while using GloPRO®. For extremely sensitive skin types, perform a patch test first before using both R45 and GloPRO® together.

We encourage people to ask “what kind of retinol” instead of “how much”. Our proprietary retinol compound is a blend of retinyl, retinol and a retinoid (all forms of Vitamin A). Concentrations in each phase of R45 The Reversal increase by 50%, so Phase 2 is 50% stronger than Phase 1, and Phase 3 is 100% stronger than Phase 1. The true litmus test of a retinol’s efficacy is color. Retinol in its raw form is yellow, so if it isn’t yellow, it doesn’t contain enough of this key active to work.

Once you’ve completed Phase 3 of R45 The Reversal, we suggest switching over to a retinol-based serum to keep your results glowing strong. Our fave is The Nightly Retinol + Peptide Repair Serum. It maintains results in between R45 boosts.

We advise against using R45 The Reversal while pregnant and nursing because of the high concentration of retinol within the product.

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